Dr. Hans-Jürgen Heidebrecht

Wissenschaftlicher Mitarbeiter

AG Membrantrenntechnik und Chromatographie

Lehrstuhl für Lebensmittel- und Bio-Prozesstechnik
ZIEL – Institute for Food & Health
Weihenstephaner Berg 1
85354 Freising

Tel.: +49 8161 71-3536

Raum: E.16

Thema der Dissertation:

From food to medicine: Process development and use of functionalized polyclonal antibodies from cow's milk for the treatment of infections caused by multi-resistant bacteria

Peer reviewed publications

Heidebrecht, Hans-Jürgen; Toro-Sierra, José; Kulozik, Ulrich (2018c): Concentration of immunoglobulins in microfiltration permeates of skim milk. Impact of transmembrane pressure and temperature on the IgG transmission using different ceramic mem-brane types and pore sizes. In: Foods 7 (7). DOI: 10.3390/foods7070101.

Heidebrecht, Hans-Jürgen; Weiss, William J.; Pulse, Mark; Lange, Anton; Gisch, Karina; Kliem, Heike et al. (2019): Treatment and Prevention of Recurrent Clostridium difficile Infection with Functionalized Bovine Anti-body-Enriched Whey in a Hamster Primary Infection Model. In: Toxins (Basel) 11 (2). DOI: 10.3390/toxins11020098.

Heidebrecht, H.-J.; Kulozik, U. (2019): Fractionation of casein micelles and minor proteins by microfiltration in diafiltration mode. Study of the transmission and yield of the immunoglobulins IgG, IgA and IgM. In: In-ternational Dairy Journal 93 (in press), pp. 1–10. DOI: 10.1016/j.idairyj.2019.01.009.

Heidebrecht, Hans-Jürgen; Kulozik, Ulrich (2019): Data concerning the fractionation of individual whey pro-teins and casein micelles by microfiltration with ceramic gradient membranes. In Data Brief, p. 104102. DOI: 10.1016/j.dib.2019.104102.

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Zü-leyha; Kulozik, Ul-rich; Förster, Beatrix (2018b): Isolation of biofunctional bovine immunoglobulin G from milk- and colostral whey with mixed-mode chromatography at lab and pilot scale. In: J Chromatogr A 1562, pp. 59–68. DOI: 10.1016/j.chroma.2018.05.046.

Heidebrecht, Hans-Jürgen; Kainz, Bernadette; Schopf, Roland; Godl, Klaus; Karcier, Zü-leyha; Kulozik, Ul-rich; Förster, Beatrix (2018a): Data concerning the chromatograph-ic isolation of bovine IgG from milk- and colostral whey. In: Data Brief 21, pp. 527–539. DOI: 10.1016/j.dib.2018.09.115.

Arndt, F.; Heidebrecht, H.-J.; Schork, N.; Schuhmann, S.; Kulozik, U.; Schütz, S. et al. (2016): Deposit layer formation during skim milk dead-end filtration with ceramic hollow fiber membranes using magnetic resonance imaging. In: Magnetic Resonance in Food Science 2016 Proceedings (16), S. 55–59. DOI: 10.1255/mrfs.11.

Hartinger, Martin; Heidebrecht, Hans-Jürgen; Schiffer, Simon; Dumpler, Joseph; Kulozik, Ulrich (2019): Milk Protein Fractionation by Means of Spiral-Wound Microfiltration Membranes. Effect of the Pressure Adjustment Mode and Temperature on Flux and Protein Permeation. In Foods 8 (6). DOI: 10.3390/foods8060180.

Hartinger, Martin; Heidebrecht, Hans-Jürgen; Schiffer, Simon; Dumpler, Joseph; Kulozik, Ulrich (2019a): Technical Concepts for the Investigation of Spatial Effects in Spiral-Wound Microfiltration Membranes. In Membranes (Basel) 9 (7). DOI: 10.3390/membranes9070080.

Hartinger, Martin; Schiffer, Simon; Heidebrecht, Hans-Jürgen; Dumpler, Joseph; Kulozik, Ulrich (2019b): Investigation on the spatial filtration performance in spiral-wound membranes – Influence and length-dependent adjustment of the transmembrane pressure. In J Membrane Sci 591, p. 117311. DOI: 10.1016/j.memsci.2019.117311.

Non peer-reviewed publications

Heidebrecht, H. J., Kulozik, U (2015): Thermal stability of bovine immunoglobulins for human health issues, Symposium Food-Nutrition-Health, Kiel, Ernährungsumschau, 62(9), 152-155.

Heidebrecht, H.-J., Kulozik, U.: Milchproteinfraktionierung mittels Mikrofiltration: Möglichkeiten zur Verbesserung der Filtrationseffizienz mit keramischen Membranen – Teil 1, molkerei-industrie 2017, Vol. 2, 30-32

Heidebrecht, H.-J., Reitmaier, M., Meyer, P., Kulozik, U.: Milchproteinfraktionierung mittels Mikrofiltration: Verwendung von Prozessnebenströmen als Diafiltrationsmedium –Teil 2, molkerei-industrie 2017, Vol., 26-29

Hartinger, M., Heidebrecht, H.-J., Arndt, F., Nirschl, H., Kulozik, U.: Milchproteinfraktionierung mittels Mikrofiltration: Welche Aussagekraft hat die Porengröße bei der Filtration mit polymeren Mikrofiltrationsmembranen? – Teil 3, molkerei-industrie 2017, Vol. 4, 51-53

Hartinger, M., Heidebrecht, H.-J., Arndt, F., Nirschl, H., Kulozik, U.: Milchproteinfraktionierung mittels Mikrofiltration: Eine Methode zur besseren anwendungsbezogenen Charakterisierung von Membranen? –Teil 4, molkerei-industrie 2017, Vol. 5, 22-23

Heidebrecht H.-J., Arndt, F., Schork, N., Schuhmann, S., Guthausen, G., Nirschl, H., Kulozik, U.: Milchproteinfraktionierung mittels Mikrofiltration: In-situ Untersuchung der Deckschichtbildung auf Hohlfaser und Mehrkanalrohrmembranen. –Teil 5, molkerei-industrie 2017, Vol. 6, 41-43

Reitmaier, M., Heidebrecht, H.-J., Kulozik, U.: Milk protein fractionation by means of microfiltration: Influence of preconcentration and diafiltration medium - part 1. International Dairy Magazine 2017, Vol. 8, 16-19

Hartinger, M., Heidebrecht, H.-J., Arndt, F., Nirschl, H., H.-J., Kulozik, U.: Milk protein fractionation by means of microfiltration: How to characterize polymeric microfiltration membranes – a new approach using a stirred test cell - part 2. International Dairy Magazine 2017, Vol. 9, 24-25

Schork, N., Heidebrecht, H.-J., Schopf, R., Arndt, F., Schuhmann, S., Guthausen, G., Nirschl, H., Kulozik, U.: Milk protein fractionation by means of microfiltration: An in-situ investigation of fouling formation on hollow fiber membranes – part 3, International Dairy Magazine 2017, Vol. 10, 38-40

Preise

2. Platz im Wettbewerb der 20 besten Doktoranden Europas auf dem Gebiet der Lebensmittelwissenschaften durch die European Federation of Chemical Engineering Food Engineering

Gewinner des Wettbewerbs "DLG Junge Ideen 2019" der Deutschen Landwirtschafts-Gesellschaft
Verleihung am 18. März 2020 https://www.dlg.org/de/lebensmittel/veranstaltungen/dlg-think-food/

Finalist beim Otto-von-Guericke-Preis 2019 -  https://youtu.be/wY1v5HUUuhw

Reisestipendium für einen hervorragenden Beitrag zum European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 19, Amsterdam, Niederlande) 

2016 Winner of the sustainability award at the 18th World Congress of Food Science and Technology (IUFoST, Dublin, Ireland)